Are Aberrant Crypt Foci (Acf) Suitable Intermediate Endpoint Biomarkers for Tumor Occurrence?
Proceedings American Association of Cancer Research. 46:5180. Interpretive Summary: Whey proteins are a collection of soluble proteins in milk and in addition to being present in milk products, they are used in many processed foods. Previous studies suggested that a whey protein hydrolysate (WPH)-based diet could protect against intestinal and colon cancer occurrence. This study examined WPH in the prevention of tumors in small and large intestines of rats. Sprague-Dawley rats were fed diets containing casein or WPH as the sole protein source. Rats received the chemical AOM to induce intestinal tumors. WPH-fed rats had decreased incidence of intestine tumors compared to CAS-fed rats. Additionally, incidence of intestinal adenomas (more severe cancers) was decreased by WPH at 23 weeks. In summary, feeding of WPH inhibits intestinal cancers in rats and suggests further studies of this dietary supplement in cancer prevention in humans. Future studies in this area will concentrate on how e
