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Are antigenic or genomic specific features responsible for enhanced pathogenicity?

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Are antigenic or genomic specific features responsible for enhanced pathogenicity?

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Although some antigenic and genomic-specific features are observed repeatedly in vv IBDVs, these features have not been shown to be responsible for any enhanced pathogenicity. Until 100 % reliable pathogenicity markers have been identified, pathogenicity testing in susceptible chickens under isolated conditions remains the only definitive method of identifying vv IBDV. Variations in the challenge protocol (breed or age of chicken, virus dose, route of inoculation) are critical, and the results should be compared with relevant references. Other laboratory tests Agar gel immunodiffusion (AGID) test This test can be used to detect viral antigen in the bursa of Fabricius. A portion of the bursa is removed, homogenised, and used as antigen in a test against known positive antiserum. This is particularly useful in the early stages of the infection, before the development of an antibody response. Immunofluorescence test This test can also be used to detect antigen in bursal tissue. Using IBD-

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