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Are chromosomal base pairs counted statistically or are they counted empirically and if so how?

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Are chromosomal base pairs counted statistically or are they counted empirically and if so how?

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Base pairs are simply nucleotides (adenine, cytosene, guanine, thymine) connected by hydrogen bonds. Each half of the human genome (23 chromosomes) is estimated to be about 3 billion base pairs long. They are counted by using molecular weight of each base pair. Each average base pair has a molecular weight of about 600, so this number is divided into the total molecular weight of the genome.

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