Are disulfiram-like reactions associated with abacavir-containing antiretroviral regimens in clinical practice?
Author(s): Barber TJ, Marett B, Waldron S, Portsmouth S, Mackie NE, Weston R, Winston A Affiliation(s): Imperial College, London, UK. Publication date & source: 2007-08-20, AIDS., 21(13):1823-4. Publication type: Case Reports Abacavir is metabolized primarily by two enzymes: alcohol dehydrogenase and gluconyl transferase. Under normal conditions, alcohol is hepatically cleared via alcohol dehydrogenase to acetaldehyde, and subsequently by acetaldehyde dehydrogenase (ACD) to acetic acid. Disulfiram acts as an ACD blocker. Abacavir may also act as an inhibitor of alcohol dehydrogenase, which raises the possibility of disulfiram-like reactions (if complete inhibition occurs) or reduced alcohol tolerance (if partial inhibition occurs) occurring with abacavir therapy.
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