Important Notice: Our web hosting provider recently started charging us for additional visits, which was unexpected. In response, we're seeking donations. Depending on the situation, we may explore different monetization options for our Community and Expert Contributors. It's crucial to provide more returns for their expertise and offer more Expert Validated Answers or AI Validated Answers. Learn more about our hosting issue here.

Are nucleotides in solution more stable than its lyophilised form?

0
Posted

Are nucleotides in solution more stable than its lyophilised form?

0

Yes. Preparations of dNTPs decompose into nucleoside di- and mono- phosphates via a disproportionation reaction. At temperatures above 4°C, lyophilised preparations of deoxynucleotides undergo disproportionation faster than nucleotides in solution. In contrast, at -20°C, the rate of degradation for both forms is less than 1% per year. Nucleotides in solution are also generally purer. Some lyophilised preparations approach 98% purity or more but rarely match the >99% achieved by extremely pure solutions. Generally, solution nucleotides are purer than the lyophilised version.

Related Questions

Thanksgiving questions

*Sadly, we had to bring back ads too. Hopefully more targeted.