Are Proton-Pump Inhibitors (PPIs) Associated with an Increased Risk of Community-Acquired Pneumonia (CAP)?
Monika A. Sarkar, MD, Sean Hennessy, PharmD, Yu-Xiao Yang, MD., *Department of Medicine, Univeristy of Pennsylvania, Philadelphia, PA and Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA.Purpose: Limited data suggest that proton-pump inhibitor use may increase the risk of developing community-acquired pneumonia. We aim to further assess the effect of recent PPI use on the risk of developing CAP in a large, population-based cohort.Methods: We conducted a nested case-control study in the General Practice Research Database (GPRD) (1987–2003). The GPRD is a computerized medical record system from the United Kingdom containing complete, prospectively-collected prescription data. The study cohort included all patients aged 18 years and with 6 months of pneumonia free follow-up in the GPRD. Cases included all patients with an incident CAP diagnosis. Up to 10 controls were selected for each case using
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