Are splice variants included in IPI as separate entries?
All annotated splice variants are included in IPI as separate entries (unless their protein sequences are identical). To this end, IPI uses UniProt isoform identifiers to explicitly cross-reference individual isoforms describe in UniProt Knowledgebase entries (e.g. P13746-1). Un annotated splice variants may be represented as independent entities or as an aggregated cluster, depending on the degree of sequence similarity. (as there is no a priori way of distinguishing between sequencing errors and genuine splice events from sequence alone.
