Are the amplitudes of visual evoked potentials sensitive indices of hangover effects after repeated doses of benzodiazepines?
Here we compared the efficacy of two electrophysiological techniques in detecting hangover effects after repeated administration (five days) of benzodiazepines. Twelve hours after the last ingestion, possible effects on evoked potentials (EPs) of the long- and short-acting benzodiazepines, flurazepam and lormetazepam, were compared here with those of placebo under a double-blind experimental condition. The EPs were recorded from occipital and parietal sites during an active discrimination of two amoeboid shapes and passive viewing of sine-wave grating patterns turned on and off. In the former task, the subject was requested to make a selective response with respect to whether the two shapes appeared the same or different and his reaction times were simultaneously recorded. Neither benzodiazepine influenced the latencies of any of the sensory and late EP components. Flurazepam’s long-acting metabolite, N-desalkylflurazepam, reduced the amplitudes of all the EP components suggesting a so
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