are the perfusion effects centrally mediated?
Since opioid receptors are located in the central nervous system as well as on the peripheral vasculature, studies from this lab focused on determining the site of action that accounts of the improvement of hepato-splanchnic perfusion during endotoxic shock. In a recent study (142), we used naloxone methyl-bromide (NMB), a NLX derivative which does not cross the blood-brain barrier, and compared its effects on perfusion to that of NLX during endotoxin shock. Selected data are shown in table 2. Consistent with our previous reports (134,135), after administration of endotoxin, NLX prevented the 60 minute decline in cardiac output, and improved perfusion in small bowel and other regions of the GI tract (effect on other regions not shown), and epididymal fat pads (adipose), but had no significant effect on the depressed renal perfusion. NMB did not prevent the decline in cardiac output, nor change perfusion of adipose tissue, suggesting that these effects were mediated via central neural m
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- are the perfusion effects centrally mediated?