Are there any drug interactions associated with BYETTA?

The effect of BYETTA to slow gastric emptying may reduce the extent and rate of absorption of orally administered drugs, so it should be used with caution in patients receiving oral medications that require rapid gastrointestinal absorption. Medications that are dependent on threshold concentrations for efficacy, such as oral contraceptives and antibiotics, should be taken at least 1 hour before BYETTA injection. If such drugs are to be administered with food, they should be taken with a meal or snack when BYETTA is not administered. Increased INR (International Normalized Ratio) sometimes associated with bleeding has been reported in postmarketing experience with concomitant use of warfarin.