Are there any problems due to resin swelling during synthesis?
We recommend resins of the POE-PS type (e. g. TentaGel) which exhibit favourable physical properties and do not change much in volume during the synthesis. Swelling is less of a problem than shrinking, which often leads to lumpy resin beds. This can be improved by a solvent change during the cycle, which also helps to break up peptide chain aggregations causing the shrinking of the resin.