Can a benzoyl peroxide wash/cleanser reduce colony counts of P. acnes?
Data are limited on the microbiologic effects of available BPO cleanser/wash formulations.[6,7] Unfortunately, there are too few studies, and a lack of comparative studies among formulations, to definitively state that any BPO cleanser/wash that is randomly selected for treatment of acne vulgaris, including over-the-counter (OTC) products, can markedly reduce colony counts of P. acnes. A two-week P. acnes microbiologic study evaluating an older formulation of a specific BPO 5% wash (N=75) demonstrated a modest reduction (46%) of P. acnes.[7,8] Another two-week P. acnes microbiologic study of a different brand BPO 10% cleanser used twice daily (N=17) confirmed a 93.5-percent reduction of P. acnes at Day 5, and a 97.5-percent reduction of P. acnes at the end of the study (Day 15).7,9 Importantly, in a skin-contact-time evaluation performed on a human skin model using the same BPO vehicle as the BPO 10% cleanser used in the microbiologic study discussed above, 20 seconds of skin contact t
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