The administration requirements differ from state to state. For instance, in Massachusetts Botox may be administered by a registered nurse as directed by a physician or other authorized prescriber, but only after a physician or other authorized prescriber has performed a medical examination of the patient. In Rhode Island, Botox can be administered under the guidance of an appropriately trained physician or advanced practice clinician (for example, a nurse practitioner or physician assistant) and only after a proper medical assessment is completed and patient consent obtained. In Connecticut the administration of Botox is considered within the scope of acceptable practices for properly trained registered nurses as long as the procedure has been ordered by a physician. Check with the American Society for Dermatologic Surgery for your state’s guidelines.