Can conventional bone marrow transplantation repopulate the stromal cells in bone marrow microenvironment?
Independent laboratories have shown that recipients of unmanipulated allogeneic bone marrow transplantation contain only host-type marrow stromal cells and MSCs in their bone marrow.21,22 These results are attributed to the inability of the conditioning regimen to ablate host marrow stroma and/or the inability of stromal progenitors to engraft. In addition, the number of MSCs is estimated to be too few in an average bone marrow graft (2-5 MSCs per 1 ´ 106 mononuclear cells, suggesting that a bone marrow graft comprised of 2 ´ 108 MNC/kg would contain 400-1000 MSCs/kg). On the other hand, a recent report noted that allogeneic osteoblasts could be detected in recipients with osteogenesis imperfecta (OI) after sibling-matched allogeneic bone marrow transplantation.23 It is not clear if this observation indicates if osteoblasts were passively transferred to the recipient, or whether MSCs present in the marrow graft were capable of homing to the bone and differentiating into osteoblasts. Ne
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- Can conventional bone marrow transplantation repopulate the stromal cells in bone marrow microenvironment?
