Can glyburide be crushed?
No , can cause Hypoglycemia. Amaryl(R) (glimepiride tablets) showed a reduced risk of early hypoglycemia after initial dose compared to glyburide, making it preferable as initial therapy for type 2 diabetes patients, according to the results of a head-to-head crossover study presented today at the American Diabetes Association (ADA) annual meeting. “The American Diabetes Association recommends monotherapy with an oral agent as a first-line treatment for type 2 diabetes patients,” said lead investigator Matthew C. Riddle, M.D., head of the section of diabetes and professor of medicine at Oregon Health Sciences University. “The results of our study show that Amaryl lacks the large ‘first-dose’ insulin secretory effect associated with glyburide. Therefore, Amaryl is a good first-choice sulfonylurea because there is less concern about unwanted early hypoglycemia.” Glyburide, a potent oral hypoglycemic agent, can precipitate severe hypoglycemia when its action is …
