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Can I use Whole-Genome amplified (WGA) samples with the Infinium assay?

April 26, 2017amplified assay infinium samples WGA whole-genome

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Can I use Whole-Genome amplified (WGA) samples with the Infinium assay?

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Illumina does not recommend using WGA samples as input for the Infinium Assay as the first step in the protocol is a WGA step. Up to a 4% decrease in call rate was observed in the limited internal testing performed. The decrease in call rate will vary depending on the specific sample and WGA method used. Additionally, any allelic bias present in the original WGA sample may be compounded by another WGA reaction.