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Can vaccinia immune globulin (VIG) be used to treat smallpox infection?

April 26, 2017globulin infection smallpox treat Used vaccinia vig

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Can vaccinia immune globulin (VIG) be used to treat smallpox infection?

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Vaccinia immune globulin (VIG) provides transient passive immunity and has been used with success in patients with vaccine-associated adverse reactions such as eczema vaccinatum, severe generalized vaccinia, milder forms of progressive vaccinia, and in patients who have experienced severe reactions after inadvertent implantation of the vaccinia virus. VIG is not effective for treating an active smallpox infection and should not be administered in such a setting. References: Fulginiti VA, Papier A, Lane JM, Neff JM, Henderson DA. Smallpox vaccination: a review, part II. Adverse events. Clin Infect Dis 2003;37:251-71. Grabenstein JD. Immunofacts: vaccines and immunologic drugs. St. Louis, MO: Wolters Kluwer Health, Inc., 2004.