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Myasthenic crisis is when treatment is insufficient. This results in muscle weakness. Cholinergic crisis is when treatment is excessive and this also results in muscle weakness. Edrophonium can be used to tell the difference between the two. Edrophonium will improve muscle strength in myasthenic crisis (increase NMJ transmission) but make muscle weakness in cholinergic crisis worse (deepen the block).
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Can you describe what is meant by myasthenic crisis and cholinergic crisis?
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