Children with moderately elevated lead levels: is chelation with DMSA helpful?
Author(s): O’Connor ME, Rich D Affiliation(s): Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA. Publication date & source: 1999-06, Clin Pediatr (Phila)., 38(6):325-31. Publication type: Clinical Trial; Randomized Controlled Trial This study evaluates the effectiveness (use under routine circumstances) of DMSA (2,3 dimercaptosuccinic acid) and environmental remediation as compared with placebo and environmental remediation on children with blood lead (BPb) levels of 30-45 micrograms/dL (1.45-2.17 mumol/L). The endpoints were BPb at 1 month and 6 months after study entry. This double-blind placebo-controlled trial involved 39 children aged 2-5 years, who were randomized to one course of DMSA or placebo. The mean BPb levels of the two groups at study entry were similar, placebo group 33.0 micrograms/dL (1.59 mumol/L) and the DMSA group 34.9 micrograms/dL (1.68 mumol/L). At 1 month (the end of treatment) the mean BPb levels of the two groups were: placebo g