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Could ligand binding ever destabilize a protein?

April 26, 2017Binding destabilize ligand protein

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Could ligand binding ever destabilize a protein?

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It’s rare, but it has happened. Usually this occurs either when the ligand induces a large conformational change in its target protein when it binds, and the bound conformation is inherently less stable, or when ligand binding disrupts a number of protein self-interactions in the binding site.