Coumadin & Floxin Question: Is there any interactions when taking Coumadin and Floxin which would increase the INR level?
Coumadin(warfarin) is an anti-coagulant used in a variety of situations to decrease the ability of the body to form clots. It acts on different “factors” in the blood necessary to start the coagulation cascade. These factors are made in the liver. Consequently, any drug that is metabolized in the liver can affect the level of coumadin in the body and the subsequent INR. INR is a measure of the decreased coagulation ability of the blood. Coumadin was initially discovered at the University of Wisconsin as a rat poison. As you can see too much of this drug will ruin your whole day. Therefore, it is very important that all your physicians and your pharmacist know that you are on coumadin. In general, antibiotics must be followed extremely closely to avoid either too much or too little coumadin. Floxin(ofloxacin) belongs to a class of drugs called quinolones. These drugs in general increase the effect of coumadin;that is, taking floxin will require your coumadin dose to be decreased. Howeve
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