Defining Vasospasm After Subarachnoid Hemorrhage. What Is the Most Clinically Relevant Definition?
Background and Purpose—Vasospasm is an important complication of subarachnoid hemorrhage, but is variably defined in the literature. Methods—We studied 580 patients with subarachnoid hemorrhage and identified those with: (1) symptomatic vasospasm, defined as clinical deterioration deemed secondary to vasospasm after other causes were eliminated; (2) delayed cerebral ischemia (DCI), defined as symptomatic vasospasm, or infarction on CT attributable to vasospasm; (3) angiographic spasm, as seen on digital subtraction angiography; and (4) transcranial Doppler (TCD) spasm, defined as any mean flow velocity >120 cm/sec. Logistic regression analysis was performed to test the association of each definition of vasospasm with various hospital complications, and 3-month quality of life (sickness impact profile), cognitive status (telephone interview of cognitive status), instrumental activities of daily living (Lawton score), and death or severe disability at 3 months (modified Rankin scale scor
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- Defining Vasospasm After Subarachnoid Hemorrhage. What Is the Most Clinically Relevant Definition?