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Do anticoagulants reduce hematocrit and hemoglobin levels?

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Do anticoagulants reduce hematocrit and hemoglobin levels?

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10

Anticoagulants will affect prothrombin or partial thromboplastin times (PT or PTT), but not hemoglobin or hematocrit. Now, if the anticoagulation causes bleeding, the H & H will go down. Bleeding can be occult (hidden), so if the H & H is decreasing, investigation for a source of bleeding is appropriate, especially in an anticoagulated patient.

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