Do blood pressure and age predict response to tacrine (THA) in Alzheimers disease?
Author(s): Schneider LS, Lyness SA, Pawluczyk S, Gleason RP, Sloane RB Affiliation(s): University of Southern California School of Medicine, Los Angeles. Publication date & source: 1991, Psychopharmacol Bull., 27(3):309-14. Publication type: Clinical Trial; Randomized Controlled Trial Recent studies in major depression suggest that a pretreatment systolic orthostatic blood pressure (PSOP) fall of greater than or equal to 10 mm Hg in response to changing from a supine to a standing position may predict response to antidepressant treatment in older depressed patients. Because orthostatic blood pressure response is regulated, in part, by central cholinergic and noradrenergic systems, and both are implicated in Alzheimer’s disease, PSOP was assessed as a predictor of initial response in Alzheimer’s disease outpatients in a treatment protocol with tacrine, a cholinesterase inhibitor. We found that the magnitude of PSOP fall and increasing age each contributed to the prediction of response t
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