Important Notice: Our web hosting provider recently started charging us for additional visits, which was unexpected. In response, we're seeking donations. Depending on the situation, we may explore different monetization options for our Community and Expert Contributors. It's crucial to provide more returns for their expertise and offer more Expert Validated Answers or AI Validated Answers. Learn more about our hosting issue here.

Do homopolymers and repetitive DNA regions impact sequencing efficiency?

April 26, 2017dna efficiency homopolymers impact regions repetitive sequencing

0

Posted

Do homopolymers and repetitive DNA regions impact sequencing efficiency?

1 Answer

0

Posted

Homopolymers do not impact sequencing. The number of uniquely alignable reads is a function of the repeat content, so this will have an impact on productivity. With longer reads and paired-end sequencing, this may be less of an issue.