Do proton pump inhibitors decrease calcium absorption?
Hansen KE, Jones AN, Lindstrom MJ, Davis LA, Ziegler TE, Penniston KL, Alvig AL, Shafer MM. University of Wisconsin Department of Medicine. Proton pump inhibitors (PPIs) increase osteoporotic fracture risk, presumably via hypochlorhydria and consequent reduced fractional calcium absorption (FCA). Existing studies provide conflicting information regarding the direct effects of PPIs on FCA. We evaluated the effect of PPI therapy on FCA. We recruited women at least five years past menopause who were not taking acid suppressants. Participants underwent three 24-hour inpatient FCA studies using the dual stable isotope method. Two FCA studies were performed one month apart to establish baseline calcium absorption. The third study occurred after taking omeprazole (40 mg/day) for 30 days. Each participant consumed the same foods during all FCA studies; study meals replicated subjects’ dietary habits based on 7-day diet diaries. Twenty-one postmenopausal women ages 58 +/- 7 years (mean +/- SD)
