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Do vardenafil and tadalafil have advantages over sildenafil in the treatment of erectile dysfunction?

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Do vardenafil and tadalafil have advantages over sildenafil in the treatment of erectile dysfunction?

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Author(s): Doggrell S Affiliation(s): School of Science, Charles Darwin University, Casuarina, Northern Territory, Australia. sheila.doggrell@cdu.edu.au Publication date & source: 2007-05, Int J Impot Res., 19(3):281-95. Epub 2006 Dec 21. Publication type: Review Erectile dysfunction (ED) affects up to 50% of men between the ages of 40 and 70 years of age. Sildenafil, vardenafil and tadalafil have all been shown to be similarly effective in the treatment of men with ED of vary etiologies, to have similar adverse effects profiles, and to improve quality-of-life by similar amounts. As these phosphodiesterase 5 (PDE5) inhibitors all increase the hypotensive effects of nitrates, they are not suitable for use in patients taking nitrates for the treatment of ischaemic heart disease. All three inhibitors must be used with caution in patients taking alpha(1)-adrenoceptors antagonists for benign prostatic hyperplasia. Although nonarteritic anterior ischaemic neuropathy has been reported in some

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