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Does BD ProEx C reagent stain tissue just like p16?

April 26, 2017BD p16 Reagent stain tissue

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Does BD ProEx C reagent stain tissue just like p16?

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No, the staining patterns are different. BD ProEx C is an antibody reagent containing antibodies to MCM2 and TOP2A proteins. The p16 reagent is an antibody specific to p16. The BD ProEx C IHC produces a nuclear staining pattern while the p16 antibody stains both the nucleus and cytoplasm. Abstract 928 from the 2005 USCAP conference in the Clinical Reference Folder (980-06163-00) describes the research studies correlating p16, MCM2, and Cyclin E as molecular markers in IHC and ICC formats.