Does calcitriol have actions independent from the vitamin D receptor in maintaining skeletal and mineral homeostasis?
Cod liver fish oil has additionally been put in the listing of food supplies of vitamin D. Aside from simply being a splendid source of vitamin D, it is usually discovered to be an excellent source of additional well being boosting nutrients and vitamins similar to vitamin A and even omega-3 fatty acids.
Hendy GN; Goltzman D Departments of Medicine, Physiology and Human Genetics, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada. PURPOSE OF REVIEW: Although the active metabolite of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), is classically appreciated to exert its calcemic and other actions via interaction with the vitamin D receptor, thereby modulating gene transcription, some of its actions cannot be explained in this way when examined in vitro. RECENT FINDINGS: Comparison of mouse models deleted for either the 25-hydroxyvitamin D-1alpha-hydroxylase enzyme (deficient in 1,25(OH)2D) or the vitamin D receptor or both has allowed an assessment of whether 1,25(OH)2D can function in the absence of the vitamin D receptor in vivo. The data indicated that calcium absorption required both the ligand and the receptor as did bone and cartilage remodeling. However, with respect to parathyroid gland function and development of the cartilaginous growth plate, calcium and 1,
