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Does Development of Cysts Increase Breast Cancer Risk?

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Does Development of Cysts Increase Breast Cancer Risk?

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Approximately 7 percent of women in Western countries develop palpable breast cysts, but the relationship between cysts and the subsequent risk of breast cancer is controversial. Microcysts are now considered to be part of the normal involutional process of breast tissue. Larger, palpable cysts may be aberrations of the involutional process, but these cysts are no longer considered a disease. The natural history of breast cysts appears to depend on the histologic type. Type 1 cysts have apocrine epithelium and contain fluid similar to intracellular fluid. In type 2 cysts, the epithelial lining is flattened and attenuated, and the fluid composition is similar to plasma. Type 1 cysts are more likely to progress to large, multiple lesions and may be associated more frequently with the development of breast cancer. Dixon and colleagues studied women referred to a Scottish breast unit to assess the relationship between cysts and the risk of breast cancer. The 1,374 women in the study were r

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