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DOES DHEA REDUCE ANEUPLOIDY?

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We previously reported that women after DHEA supplementation produce statistically significantly more chromosomally normal (euploid) embryos. We at that time, however, cautioned from reaching the conclusion that DHEA reduces chromosomal abnormalities (aneuploidy) and noted that our finding could be due to the fact that DHEA appears to increase egg and embryo numbers, which, of course, would also increase the number of euploid embryos. At the same time we, however, also pointed out that DHEA, at least theoretically, also could have an affect on chromosomal abnormality rates (ploidy), since we believe that DHEA somehow affects the whole 4.5 months long follicular recruitment process and, therefore, also could affect ploidy. As women age, the rate of aneuploidy in their embryos increases. As a consequence of more chromosomally abnormal embryos, their miscarriage rates go up with advancing age. This is exactly the reason why the expected number of miscarriages in our study group of women ... more
centerforhumanreprod.com
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