Does Jadelle use affect lipid and carbohydrate metabolism?
Serum lipoprotein levels were altered in three clinical studies involving 544 women using Jadelle. Levonorgestrel rod users had mean decreases from baseline in total cholesterol, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol of approximately 12 percent, 14 percent, and 10 percent, respectively. Triglyceride levels decreased about 25 percent from pretreatment values. Although these decreases were statistically significant, all mean values remained within the normal ranges. The long-term clinical effects of these changes have not been determined. Women who are being treated for hyperlipidemias should be followed closely if they elect to use Jadelle. Some progestins may elevate LDL levels, thereby making the control of hyperlipidemias more difficult. The effect of levonorgestrel-containing implants on carbohydrate metabolism appears to be minimal. During the Norplant postmarketing surveillance study, diabetes mellitus developed in Norplant users
