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Does naloxone have functional significant activity on medial thalamic neurons?

April 26, 2017activity center Functional medial naloxone National Neurons PubMed SIGNIFICANT thalamic

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Does naloxone have functional significant activity on medial thalamic neurons?

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Local administration (microiontophoretically) of naloxone was tested in 57 parafascicularis thalamic (PF) neurons of morphine-naive and morphine-dependent rats. In morphine-naive rats microiontophoretic applications of naloxone induced changes in 52% of the PF neurons. Reduction in neuronal activity was observed in the majority of them; this reduction phenomena exhibited dose response characteristics, i.e., each incremental naloxone dose caused further decrease of the neuronal discharges. In morphine-dependent animals, 64% of the PF neurons were affected. The changes seen after naloxone were mainly increases of electrical discharges (i.e. the opposite effects obtained in morphine-naive animals).