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Does nitrous oxide antagonize sevoflurane-induced hypnosis?

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Does nitrous oxide antagonize sevoflurane-induced hypnosis?

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T. Katoh, K. Ikeda and H. Bito Department of Anaesthesiology and Intensive Care Medicine, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu, 431-31 Japan We have studied 64 ASA I and II patients (aged 20-60 yr) to determine if nitrous oxide affects sevoflurane requirement for achieving 50% probability of no movement in response to verbal commands (MACawake). Patients were allocated randomly to one of four nitrous oxide concentration groups (0, 20, 40 and 60 vol.%). Patients in each group received sevoflurane at two different end-tidal concentrations according to a predetermined randomization table. After steady state sevoflurane and nitrous oxide concentrations had been maintained for at least 15 min, patients were assessed as being awake or asleep. The MACawake for sevoflurane was 0.63% and this was reduced significantly in a non-linear manner by increasing nitrous oxide concentration. A 50% reduction in MACawake was produced by a nitrous oxide concentration of 45%. T

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