Does Plasma Resistance to Antiretroviral Drugs Predict HIV Resistance Transmitted during Heterosexual Contact?
Conley LJ, Bush TJ, Lennox JL, Wright TC, Usgiris AJ, Evans-Strickfaden T, Vick MJ, Hart CE, Ellerbrock TV; Conference on Retroviruses and Opportunistic Infections. Abstr 10th Conf Retrovir Oppor Infect Feb 10 14 2003 Hynes Conv Cent Boston Mass USA Conf Retrovir Oppor Infect 10th 2003 Boston Mass. 2003 Feb 10-14; 10: abstract no. 620. CDC, Atlanta, GA BACKGROUND: Previously, we demonstrated that cellular replication of HIV occurs in vaginal secretions, and antiretroviral (ARV) therapy reduces the amount of HIV RNA in these secretions. In this analysis, we compared the development of ARV resistance in plasma to that in vaginal secretions to determine whether plasma resistance predicts HIV resistance transmitted during heterosexual contact.METHODS: During 1996-2000, blood and vaginal lavages were collected at 987 clinic visits of 135 HIV-infected women enrolled in the Emory Vaginal Ecology Study. This analysis includes samples from 113 clinic visits of 22 women who did not respond to AR