Does the cancer accompanying acanthosis nigricans contain endocrine cells of the APUD series?
Following the publication of Hage & Hage, who believe that gastric cancers accompanying malignant acanthosis nigricans might constitute a specific group of carcinomas in which cells from parts of the tumor arise from the APUD-series of endocrine cells, carcinomas of 2 patients with malignant acanthosis nigricans were subjected to investigation. There were no APUD-cells in the adenocarcinomas studied but they were present in the overlying mucosa. It is known, moreover, that internal carcinomas not accompanying malignant acanthosis nigricans may contain APUD cells.
