Does the oligonucleotide sequence have an impact on the synthesis success?
Yes, it does. The synthesis yield is reduced together with increasing length of the oligonucleotide (the proportion of shorter incompletely synthesized chains rises), and it also depends directly on the sequence. Chains with a high representation of G and A that show lower coupling provide a markedly lower yield than chains with a high proportion of C and T. The lowest yield is shown by pure chains of polypurines – See here for more information >>.
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