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Does transcription by RNA polymerase play a direct role in the initiation of replication?

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Does transcription by RNA polymerase play a direct role in the initiation of replication?

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AB Hassan and PR Cook CRC Nuclear Structure and Function Research Group, Sir William Dunn School of Pathology, University of Oxford, UK. RNA polymerases have been implicated in the initiation of replication in bacteria. The conflicting evidence for a role in initiation in eukaryotes is reviewed.

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