Does wearing a noseclip during inhalation improve lung deposition?
Author(s): Kohler E, Sollich V, Schuster-Wonka R, Huhnerbein J, Jorch G Affiliation(s): Department of Paediatrics, Otto von Guericke University, Magdeburg, Germany. elke.koehler@medizin.uni-magdeburg.de Publication date & source: 2004-06, J Aerosol Med., 17(2):116-22. Publication type: Clinical Trial; Randomized Controlled Trial Using nebulization, only a small proportion of the dose reaches the lungs, while the remainder is swallowed, exhaled into the atmosphere, or remains in the nebulizer. It was the purpose of this study to investigate whether wearing a noseclip during inhalation can improve lung deposition. Relative lung deposition was compared by inhalation of the marker substance, sodium cromoglycate (SCG), and measurement of urinary excretion of SCG. The SCG absorption half-life allows one to differentiate indirectly between a more or less peripheral deposition. Ten CF patients (9-18 years old) inhaled, under routine conditions, a solution containing 20 mg of SCG in a randomize
