Does Wellbutrin offer the same efficacy as Wellbutrin SR?
I couldn’t find direct comparison data, just one statement that XL “could be marginally more effective than SR,” but without any references. The Cochrane systematic review on antidepressants and cessation does not mention which dose form of bupropion to use — all the trials I can find have used the sustained-release versions. There is a debate among smoking cessation experts about whether 150 vs 300 mg/day is best — lower side effects vs slightly higher efficacy.
