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Does WGA (whole genome amplified DNA) work well with the genotyping?

April 26, 2017amplified dna genome Genotyping WGA

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Does WGA (whole genome amplified DNA) work well with the genotyping?

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We’ve have variable success using WGA DNA. The best results are with samples that began with high quality genomic DNA. It appears that heterozygous results may be trusted, but some fraction of the homozygous genotypes will be spurious. This is probably due to selective amplification of one allele in the WGA process.