Ectopic, usually diffusely hyperplastic adrenals, and don progresses because the patient dies soon after the disease becomes apparent?
Dr. Caplan answered: With regard to your second question, diffuse hyperplasia may or may not progress to nodular hyperplasia – the morphology is not as important as the physiologic effect. That’s why in the revised notes I said diffuse or nodular hyperplasia. As far as paraneoplastic/ectopic Cushing syndrome, you are correct, typically, especially in the case of small cell carcinoma of the lung, the disease is so rapidly progressive that the direct neoplastic effects and cachexia greatly overshadow the hormonal effects – untreated small cell CA results in death in about 4 months.
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