How accurately does prostate biopsy Gleason score predict pathologic findings and disease free survival?
Narain V; Bianco FJ; Grignon DJ; Sakr WA; Pontes JE; Wood DP Department of Urology, Wayne State University School of Medicine, Karmanos Cancer Institute, Detroit, MI 48201, USA. OBJECTIVE: Due to the significant impact on prognosis by subgrouping of prostatectomy Gleason scores 7, we undertook this study to answer whether the biopsy Gleason score was as predictive of disease free survival and assess the correlation with the prostatectomy Gleason score in a modern prostatectomy series. METHODS: An analysis of 1,031 patients who underwent radical prostatectomy for clinically localized prostate cancer was performed. All data was prospectively collected. The Gleason score was categorized into 3 different groups ( 7) for biopsy and prostatectomy specimens. Disease free survival was then analyzed for each group. Discrepancies between scores and outcomes were evaluated. RESULTS: Accurate correlation was noted in 54.8, 66.8, and 47.4% of Gleason scores 7, respectively. Overall accuracy was 58.
