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How are drug discovery, development, and marketing affected by pharmacogenomics?

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How are drug discovery, development, and marketing affected by pharmacogenomics?

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In the past, drug companies have focused primarily on blockbuster drugs – drugs that could be marketed to a large portion of the general population. Each of these drugs took hundreds of millions of dollars and years of research and clinical testing before it was cleared by the FDA and released to the market. For every blockbuster, there were numerous drugs that were orphaned (shelved) during the development process. Some of these drugs were only effective for a small percentage of those enrolled in clinical trials; others had too many associated side effects and complications. Each of the blockbusters released was also associated with rare but sometimes serious complications, and some complications that were not evident during clinical trials emerged with long term use. When a large number of people began taking these medications, even a tiny percentage of rare complications could become a significant number of affected patients. In some cases, these blockbusters have had to be removed

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