How are Macrophages Activated?
In order to function defensively, the Macrophages must pass through a state of activation which involves certain form and structure changes. Most importantly, a sequence of metabolic changes occurs which results in the production of a series of cytokines. Cytokines act as protein internal regulators of the immune system. Activation can be initiated by a variety of different stimuli such as endotoxin, bacteria, viruses or chemicals.
