How Are Proton Pump Inhibitors Different from H2 Blockers?
How Are Proton Pump Inhibitors Different from H2 Blockers?Answer: Both Proton Pump Inhibitors (PPIs) and H2 Blockers suppress gastric acid secretion. They are, however, different in how they do this. While PPIs shut down the cell pumps that maintain the acidic environment in the stomach, H2 Blockers work by blocking signals generated by histamine receptors on cells that are responsible for acid secretion. PPIs have a delayed onset of action, while H2 blockers begin working within an hour. PPIs work for a longer period of time; most last up to 24 hours, and the effects may last up to three days. H2 Blockers, however, usually only work up to 12 hours. Proton Pump Inhibitors include: • Aciphex (raberprazole) • Nexium (esomeprazole) • Prevacid (lans
