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How can I know that using a high concentration minoxidil solution and/or lotion isn’t an overdose and/or won’t be counterproductive to hair growth?

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How can I know that using a high concentration minoxidil solution and/or lotion isn’t an overdose and/or won’t be counterproductive to hair growth?

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A. Minoxidil has to have a serum concentration of 20 ng/mL to have any hemodynamic or other systemic effect in the human body. Allowing for 1.7% absorption of minoxidil from topical application, a 2% minoxidil solution will result in 0.6 ng/ mL and a 5% minoxidil solution will result in 1.2 ng / mL of minoxidil in the serum. So, there is more than a 16-fold safety margin from the use of 5% topical minoxidil and a 5-fold safety margin with the use of a 15% topical minoxidil solution.

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