How did EBA manage to solve the high cell density issues?
Upfront provided EBA technology that uniquely combined the disposable EBA one-step procedure with direct crude feedstock processing. There is no longer the need to centrifuge cells to release trapped MAbs from the biomass as they can be extracted directly from the fermenter using our 2nd Generation EBA ultrahigh density adsorbent beads. With EBA, there are also no clogging issues related to scale up. Unlike classical packed bed columns, any bed height can be used without the problem of back pressure. As there is no need for pressurized vessels, our technology is economical and the columns can be disposed of with low capital costs and a process can be run with any peristaltic pump because only very low pressure is needed. Q10: Can you give other examples of companies working with high cell densities who can benefit from EBA? An example would be companies working with expressions of microbial systems, such as E. coli or yeast. In many instances, these companies are working with cell homo
