Important Notice: Our web hosting provider recently started charging us for additional visits, which was unexpected. In response, we're seeking donations. Depending on the situation, we may explore different monetization options for our Community and Expert Contributors. It's crucial to provide more returns for their expertise and offer more Expert Validated Answers or AI Validated Answers. Learn more about our hosting issue here.

How do chromosomes bi-orient on the mitotic spindle?

chromosomes mitotic spindle
0
10 Posted

How do chromosomes bi-orient on the mitotic spindle?

0
10

Our recent data suggest that sister centromeres temporarily attach to microtubules from the same spindle pole (mono-orientation). We discovered that the yeast orthologue of the Aurora B-INCENP protein kinase complex, known as Ipl1-Sli15, is necessary to correct mono-orientation to bi-orientation (ref 5). To promote bi-orientation, centromere-spindle pole connections must be re-oriented if tension is not exerted on the connections. The Ipl1-Sli15 kinase complex facilitates this re-orientation until traction of sister centromeres towards opposite spindle poles creates tension in the surrounding chromatin. We therefore propose that Ipl1-Sli15 is a crucial component of an error-correcting mechanism that promotes bi-orientation.

Related Questions

Thanksgiving questions

*Sadly, we had to bring back ads too. Hopefully more targeted.