Zestra was designed to be gently applied onto the clitoris and labia (vaginal lips) before or during foreplay. It can be used during vaginal sex, manual stimulation and masturbation. The effects generally begin within three to five minutes peak at 10 minutes and last up to 45 minutes. If you use a personal lubricant for comfort during sex, apply Zestra first. Wait five minutes for Zestra to begin to work, then apply the lubricant. You must apply Zestra first to experience the Zestra Rush™. For more instructions.